This article offers a comprehensive review of recent advanced liquid biopsy technologies that utilize novel biocompatible optical nanomaterials, including fluorescence, colorimetric, photoelectrochemical, and Raman broad-spectrum-based biosensors. Liquid biopsy is an efficient diagnostic/prognostic tool for tumor-derived component detection in peripheral circulation and other body fluids. Early and precise detection of tumor biomarkers provides. A team of scientists from Israel and Russia has developed a novel, straightforward, and low-cost fiber optic technology. It allows for the testing of liquid biological samples. Optical nanomaterials with excellent light absorption, luminescence, and.